RT Journal Article
T1 Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
A1 Barradas, Marta
A1 Plaza, Adrián
A1 Colmenarejo, Gonzalo
A1 Lázaro, Iolanda
A1 Costa-Machado, Luis Filipe
A1 Martín-Hernández, Roberto
A1 Micó, Victor
A1 López-Aceituno, José Luis
A1 Herranz, Jesús
A1 Pantoja, Cristina
A1 Tejero, Hector
A1 Diaz-Ruiz, Alberto
A1 Al-Shahrour, Fatima
A1 Daimiel, Lidia
A1 Loria Kohen, Viviana Constanza
A1 Ramírez de Molina, Ana
A1 Efeyan, Alejo
A1 Serrano, Manuel
A1 Pozo, Oscar J.
A1 Sala-Vila, Aleix
A1 Fernández-Marcos, Pablo J.
A2 Springer Science and Business Media LLC, 
AB Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.
PB Nature Portfolio
SN 2041-1723
YR 2022
FD 2022-09-27
LK https://hdl.handle.net/20.500.14352/104101
UL https://hdl.handle.net/20.500.14352/104101
LA eng
NO Barradas M, Plaza A, Colmenarejo G, Lázaro I, Costa-Machado LF, Martín-Hernández R, Micó V, López-Aceituno JL, Herranz J, Pantoja C, Tejero H, Diaz-Ruiz A, Al-Shahrour F, Daimiel L, Loria-Kohen V, Ramirez de Molina A, Efeyan A, Serrano M, Pozo OJ, Sala-Vila A, Fernandez-Marcos PJ. Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity. Nat Commun. 2022 Sep 27;13(1):5677.
NO Gobierno Regional de la Comunidad de Madrid
NO Asociación Española contra el Cáncer
NO Ministerio de Ciencia, Innovación y Universidades
NO Fundación Ramón Areces
NO Hospital Ramón y Cajal
NO Fundación “laCaixa”
NO Portuguese Foundation for Science and Technology
DS Docta Complutense
RD 17 abr 2025