RT Journal Article
T1 Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells
A1 Zhao, Yongxia
A1 Ye, Xiaochun
A1 Xiong, Zhifeng
A1 Ihsan, Awais
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Anadón Navarro, Arturo Ramón
A1 Wang, Xu
A1 Martínez Caballero, María Aranzazu
AB Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS) levels are a recognized hallmark of cancer and an important aspect of cancer treatment research. Abnormally elevated ROS levels are often attributable to alterations in cellular metabolic activities and increased oxidative stress, which affects both the development and maintenance of cancer. Moderately high levels of ROS are beneficial to maintain tumor cell genesis and development, while toxic levels of ROS have been shown to be an important force in destroying cancer cells. ROS has become an important anticancer target based on the proapoptotic effect of toxic levels of ROS. Therefore, this review summarizes the role of increased ROS in DNA damage and the apoptosis of cancer cells caused by changes in cancer cell metabolism, as well as various anticancer therapies targeting ROS generation, in order to provide references for cancer therapies based on ROS generation.
PB MDPI
YR 2023
FD 2023-06-27
LK https://hdl.handle.net/20.500.14352/104536
UL https://hdl.handle.net/20.500.14352/104536
LA eng
NO Zhao, Y.; Ye, X.; Xiong, Z.; Ihsan, A.; Ares, I.; Martínez, M.; Lopez-Torres, B.; Martínez-Larrañaga, M.-R.; Anadón, A.; Wang, X.; et al. Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells. Metabolites 2023, 13, 796. https://doi.org/ 10.3390/metabo13070796
NO 2023 Descuento MDPI
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 8 abr 2025