RT Journal Article
T1 Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
A1 García Culebras, Alicia
A1 Cuartero Desviat, María Isabel
A1 Peña Martínez, Carolina Belén
A1 Moraga Yébenes, Ana
A1 Vázquez Reyes, Sandra
A1 De Castro Millán, Francisco Javier
A1 Cortes Canteli, Marta
A1 Lizasoaín Hernández, Ignacio
A1 Moro Sánchez, María Ángeles
AB Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post-stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte-derived macrophages) to central nervous system (CNS)-associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil-dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.
PB Wiley
SN 0007-1188
SN 1476-5381
YR 2023
FD 2023-07-07
LK https://hdl.handle.net/20.500.14352/103367
UL https://hdl.handle.net/20.500.14352/103367
LA eng
NO García-Culebras A, Cuartero MI, Peña-Martínez C, Moraga A, Vázquez-Reyes S, de Castro-Millán FJ, Cortes-Canteli M, Lizasoain I, Moro MÁ. Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets? Br J Pharmacol. 2024 Mar;181(6):777-798. doi: 10.1111/bph.16159
DS Docta Complutense
RD 4 abr 2025