RT Journal Article
T1 Determinants of HIV-1 Late Presentation in Patients Followed in Europe.
A1 Miranda, Mafalda N. S.
A1 Pingarilho, Marta
A1 Pimentel, Victor
A1 Martins, Maria do Rosário O.
A1 Vandamme, Anne-Mieke
A1 Bobkova, Marina
A1 Böhm, Michael
A1 Seguin-Devaux, Carole
A1 Paredes, Roger
A1 Zazzi, Maurizio
A1 Rubio García, Rafael
A1 Incardona, Francesca
A1 Abecasis, Ana
AB To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89,851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmission, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.
PB MDPI
YR 2021
FD 2021-07-02
LK https://hdl.handle.net/20.500.14352/105353
UL https://hdl.handle.net/20.500.14352/105353
LA eng
NO Miranda MNS, Pingarilho M, Pimentel V, Martins MDRO, Vandamme AM, Bobkova M, Böhm M, Seguin-Devaux C, Paredes R, Rubio R, Zazzi M, Incardona F, Abecasis A. Determinants of HIV-1 Late Presentation in Patients Followed in Europe. Pathogens. 2021 Jul 2;10(7):835.
DS Docta Complutense
RD 24 abr 2025