RT Journal Article
T1 Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow’s Milk Protein Allergy under a Restricted Diet
A1 Díaz, María
A1 Guadamuro, Lucía
A1 Espinosa Martos, Irene
A1 Mancabelli, Leonardo
A1 Jiménez, Santiago
A1 Molinos-Norniella, Cristina
A1 Pérez-Solis, David
A1 Milani, Christian
A1 Rodríguez Gómez, Juan Miguel
A1 Ventura, Marco
A1 Bousoño, Carlos
A1 Gueimonde, Miguel
A1 Margolles, Abelardo
A1 Díaz, Juan
A1 Delgado, Susana
AB Cow’s milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates. After this period, stool samples were obtained and tolerance development was evaluated by oral challenges. A control group of 10 age-matched healthy infants on an unrestricted diet were included in the study. Microbiota composition, short-chain fatty acids, calprotectin, and transforming growth factor (TGF)-β1 levels were determined in fecal samples from both groups. Infants with NIM-CMPA that consumed vegetable protein-based formulas presented microbiota colonization patterns different from those fed with an extensively hydrolyzed formula. Differences in microbiota composition and fecal parameters between NIM-CMPA and healthy infants were observed. Non-allergic infants showed a significantly higher proportion of Bacteroides compared to infants with NIM-CMPA. The type of protein hydrolysate was found to determine gut microbiota colonization and influence food allergy resolution in NIM-CMPA cases.
PB MDPI
SN 2072-6643
YR 2018
FD 2018-10-11
LK https://hdl.handle.net/20.500.14352/12529
UL https://hdl.handle.net/20.500.14352/12529
LA eng
NO Instituto Danone
DS Docta Complutense
RD 11 abr 2025