RT Journal Article
T1 Differences in Patterns of Stimulant Use and Their Impact on First-Episode Psychosis Incidence: An Analysis of the EUGEI Study
A1 Elisa Rodríguez-Toscano, Clara Alloza, David Fraguas, Manuel Durán-Cutilla, Laura Roldán, Teresa Sánchez-Gutiérrez, , Gonzalo López-Montoya, Mara Parellada, Carmen Moreno, Charlotte Gayer-Anderson, Hannah E. Jongsma, Marta Di Forti, Diego Quattrone, Eva Velthorst,Lieuwe de Haan, Jean-Paul Selten, Andrei Szöke, Pierre-Michel Llorca, Andrea Tortelli, Julio Bobes,Miguel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Ilaria Tarricone, Domenico Berardi,Mirella Ruggeri, Antonio Lasalvia, Laura Ferraro, Caterina La Cascia, Daniele La Barbera,Paulo Rossi Menezes, Cristina Marta Del-Ben, EU-GEI WP2 Group, Bart P. Rutten, Jim van Os,Peter B. Jones, Robin M. Murray, James B. Kirkbride, Craig Morgan, Covadonga M. Díaz-Caneja,and Celso Arango
A1 Rodríguez Toscano, Elisa
A1 Alloza, C.
A1 Fraguas Herráez, David
A1 Durán-Cutilla, M.
A1 Roldán Díaz, Laura
A1 Sánchez-Gutiérrez, T.
A1 López-Montoya, G.
A1 Parellada Redondo, María José
A1 Moreno Ruiz, María del Carmen
A1 Gayer-Anderson, C.
A1 Jongsma, H.E.
A1 Di Forti, M.
A1 Quattrone, D.
A1 Velthorst, E.
A1 De Haan, L.
A1 Selten, J.-P.
A1 Szöke, A.
A1 Llorca, P.-M.
A1 Tortelli, A.
A1 Bobes, J.
A1 Bernardo, M.
A1 Sanjuán, J.
A1 Luis Santos, J.
A1 Arrojo, M.
A1 Tarricone, I.
AB BackgroundUse of illegal stimulants is associated with an increased risk of psychotic disorder. However, the impact of stimulant use on odds of first-episode psychosis (FEP) remains unclear. Here, we aimed to describe the patterns of stimulant use and examine their impact on odds of FEP.MethodsWe included patients with FEP aged 18–64 years who attended psychiatric services at 17 sites across 5 European countries and Brazil, and recruited controls representative of each local population (FEP = 1130; controls = 1497). Patterns of stimulant use were described. We computed fully adjusted logistic regression models (controlling for age, sex, ethnicity, cannabis use, and education level) to estimate their association with odds of FEP. Assuming causality, we calculated the population-attributable fractions for stimulant use associated with the odds for FEP.FindingsPrevalence of lifetime and recent stimulant use in the FEP sample were 14.50% and 7.88% and in controls 10.80% and 3.8%, respectively. Recent and lifetime stimulant use was associated with increased odds of FEP compared with abstainers [fully adjusted odds ratio 1.74,95% confidence interval (CI) 1.20–2.54, P = .004 and 1.62, 95% CI 1.25–2.09, P < .001, respectively]. According to PAFs, a substantial number of FEP cases (3.35% [95% CI 1.31–4.78] for recent use and 7.61% [95% CI 3.68–10.54] for lifetime use) could have been prevented if stimulants were no longer available and the odds of FEP and PAFs for lifetime and recent stimulant use varied across countries.InterpretationIllegal stimulant use has a significant and clinically relevant influence on FEP incidence, with varying impacts across countries.
PB Oxford Academic
YR 2023
FD 2023-07-19
LK https://hdl.handle.net/20.500.14352/133497
UL https://hdl.handle.net/20.500.14352/133497
LA eng
NO Elisa Rodríguez-Toscano, Clara Alloza, David Fraguas, Manuel Durán-Cutilla, Laura Roldán, Teresa Sánchez-Gutiérrez, Gonzalo López-Montoya, Mara Parellada, Carmen Moreno, Charlotte Gayer-Anderson, Hannah E Jongsma, Marta Di Forti, Diego Quattrone, Eva Velthorst, Lieuwe de Haan, Jean-Paul Selten, Andrei Szöke, Pierre-Michel Llorca, Andrea Tortelli, Julio Bobes, Miguel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Ilaria Tarricone, Domenico Berardi, Mirella Ruggeri, Antonio Lasalvia, Laura Ferraro, Caterina La Cascia, Daniele La Barbera, Paulo Rossi Menezes, Cristina Marta Del-Ben, EU-GEI WP2 Group , Bart P Rutten, Jim van Os, Peter B Jones, Robin M Murray, James B Kirkbride, Craig Morgan, Covadonga M Díaz-Caneja, Celso Arango, Differences in Patterns of Stimulant Use and Their Impact on First-Episode Psychosis Incidence: An Analysis of the EUGEI Study, Schizophrenia Bulletin, Volume 49, Issue 5, September 2023, Pages 1269–1280,
DS Docta Complutense
RD 19 may 2026