%0 Journal Article
%A Martínez Naves, Eduardo
%A Reche Gallardo, Pedro Antonio
%A Lafuente Duarte, María Esther
%T Recognition of the ligand-type specificity of classical and non-classical MHC I proteins.
%D 2011
%@ 1873-3468
%U https://hdl.handle.net/20.500.14352/41998
%X Functional characterization of proteins belonging to the MHC I superfamily involves knowing their cognate ligands, which can be peptides, lipids or none. However, the experimental identification of these ligands is not an easy task and generally requires some a priori knowledge of their chemical nature (ligand-type specificity). Here, we trained k-nearest neighbor and support vector machine classifiers that predict the ligand-type specificity MHC I proteins with great accuracy. Moreover, we applied these classifiers to human and mouse MHC I proteins of uncharacterized ligands, obtaining some results that can be instrumental to unravel the function of these proteins.
%~