RT Journal Article
T1 Recognition of the ligand-type specificity of classical and non-classical MHC I proteins.
A1 Martínez Naves, Eduardo
A1 Reche Gallardo, Pedro Antonio
A1 Lafuente Duarte, María Esther
AB Functional characterization of proteins belonging to the MHC I superfamily involves knowing their cognate ligands, which can be peptides, lipids or none. However, the experimental identification of these ligands is not an easy task and generally requires some a priori knowledge of their chemical nature (ligand-type specificity). Here, we trained k-nearest neighbor and support vector machine classifiers that predict the ligand-type specificity MHC I proteins with great accuracy. Moreover, we applied these classifiers to human and mouse MHC I proteins of uncharacterized ligands, obtaining some results that can be instrumental to unravel the function of these proteins.
PB Federation of European Biochemical Societies
SN 1873-3468
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/41998
UL https://hdl.handle.net/20.500.14352/41998
LA eng
NO Martínez Naves, E., Reche Gallargo, P. A. & Lafuente Duarte, M. E. et al. «Recognition of the Ligand-Type Specificity of Classical and Non-Classical MHC I Proteins». FEBS Letters, vol. 585, n.o 21, noviembre de 2011, pp. 3478-84. DOI.org (Crossref), https://doi.org/10.1016/j.febslet.2011.10.007.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Sanidad (España)
NO Comunidad Autonoma de Madrid
DS Docta Complutense
RD 4 abr 2025