RT Journal Article
T1 Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: from Laboratory Scales to Industrial Reactors
A1 Álvarez, Rafael
A1 Muñoz-Piña, Sandra
A1 González, Maria U.
A1 Izquierdo Barba, Isabel
A1 Fernández-Martín, Iván
A1 Jiménez Rico, Víctor
A1 Arcos Navarrete, Daniel
A1 García-Valenzuela, Aurelio
A1 Palmero, Alberto
A1 Vallet Regí, María Dulce Nombre
A1 González-Elipe, Agustín R.
A1 García-Martín, José R.
AB Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (Depuy Synthes) and a pseudo-rectangular bone plate extracted from a patient have been coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments have been performed: analysis of bacterial adhesion and biofilm formation, and osteoblasts-bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior towards osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.
PB MDPI
SN 2079-4991
YR 2019
FD 2019-08-28
LK https://hdl.handle.net/20.500.14352/13527
UL https://hdl.handle.net/20.500.14352/13527
LA eng
NO RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba)ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba)RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Comunidad de Madrid
DS Docta Complutense
RD 2 may 2025