RT Journal Article
T1 Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis
A1 Cañadas Benito, Olga
A1 Olmeda Lozano, Bárbara
A1 Alonso Eugenio, Alejandro
A1 Pérez-Gil, Jesús
AB Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air–liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid–protein and protein–protein interactions contribute to the proper maintenance of an operative respiratory surface.
PB MDPI
SN 1661-6596, ESSN 1422-0067
YR 2020
FD 2020-05-25
LK https://hdl.handle.net/20.500.14352/6496
UL https://hdl.handle.net/20.500.14352/6496
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Comunidad de Madrid
DS Docta Complutense
RD 30 abr 2024