RT Journal Article
T1 Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
A1 Marchena-Fernández, Miguel
A1 Sánchez-Camacho Blázquez, Cristina
A1 Muñoz-Sáez, Emma
A1 Macías-Castellano, Alba
A1 Castro Soubriet, Fernando de
AB The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.
PB Wolters Kluwer Medknow Publications
SN 1673-5374
YR 2025
FD 2025-08-13
LK https://hdl.handle.net/20.500.14352/125270
UL https://hdl.handle.net/20.500.14352/125270
LA eng
NO Marchena-Fernández M, Sánchez-Camacho C, Muñoz-Sáez E, Macías-Castellano A, de Castro Soubriet F (2026). Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination. Neural Regen Res. https://doi.org/10.4103/NRR.NRR-D-25-00005
NO Supported by the Spanish Government (PID2022-143110OB-IOO), Merck Foundation (20234599), and Universidad Camilo José Cela (CEIDI_VI_08_06_XI_EMYDEM).
NO Ministerio de Ciencia e Innovación (España)
NO Merck Foundation (Reino Unido)
NO Universidad Camilo José Cela (España)
DS Docta Complutense
RD 27 feb 2026