%0 Journal Article
%A Alkozi, Hanan Awad
%A Franco, Rafael
%A Pintor, Jesús
%T Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases
%D 2017
%@ 1663-4365
%U https://hdl.handle.net/20.500.14352/18258
%X Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
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