RT Journal Article
T1 Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases
A1 Alkozi, Hanan Awad
A1 Franco, Rafael
A1 Pintor, Jesús
AB Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
PB Frontiers Media
SN 1663-4365
YR 2017
FD 2017-10-12
LK https://hdl.handle.net/20.500.14352/18258
UL https://hdl.handle.net/20.500.14352/18258
LA eng
NO This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Sanidad de España
NO RETICS (Redes Temáticas de Investigación en Ciencias de la Salud)
DS Docta Complutense
RD 1 may 2024