RT Journal Article
T1 OXY-SCORE: a new perspective for left ventricular hypertrophy diagnosis
A1 Quintana Villamandos, María Begoña
A1 Pazó Sayós, laia
A1 González del Pozo, Irene
A1 Rodríguez Rodríguez, Pilar
A1 Bellón, Jose María
A1 Pedraz Prieto, Álvaro
A1 Pinto, Ángel
A1 González, Mª del Carmen
AB Background:A recently developed global indicator of oxidative stress (OXY-SCORE), by combining individual plasma biomarkers of oxidative damage and antioxidant capacity, has been validated in several pathologies, but not in left ventricular hypertrophy (LVH). The aim of this study was to design and calculate a plasma oxidative stress global index for patients with LVH.Methods:A total of 70 consecutive adult patients were recruited in our institution and assigned to one of the two study groups (control group/LVH group) by an echocardiography study. We evaluated plasmatic biomarkers of oxidative damage (malondialdehyde and thiolated proteins) and antioxidant defense (total thiols, reduced glutathione, total antioxidant capacity, catalase, and superoxide dismutase activities) by spectrophotometry/fluorimetry in order to calculate a plasma oxidative stress global index (OXY-SCORE) in relation to LVH.Results:The OXY-SCORE exhibited a highly significant difference between the groups (p < 0.001). The area under the receiver operating characteristic curve was 0.74 (95% confidence interval (CI), 0.62–0.85; p < 0.001). At a cut-off value of −1, the 68.6% sensitivity and 68.6% specificity values suggest that OXY-SCORE could be used to screen for LVH. A multivariable logistic regression model showed a positive association (p = 0.001) between OXY-SCORE and LVH [odds ratio = 0.55 (95% CI, 0.39–0.79)], independent of gender, age, smoking, glucose, systolic and diastolic arterial pressure, dyslipidemia, estimated glomerular filtration rate, body mass index, and valvular/coronary disease.Conclusion:OXY-SCORE could help in the diagnosis of LVH and could be used to monitor treatment response.
PB SAGE Publications Ltd
SN 2040-6223
YR 2020
FD 2020-06-27
LK https://hdl.handle.net/20.500.14352/116573
UL https://hdl.handle.net/20.500.14352/116573
LA spa
NO Quintana-Villamandos B, Pazó-Sayós L, González del Pozo I, et al. OXY-SCORE: a new perspective for left ventricular hypertrophy diagnosis. Therapeutic Advances in Chronic Disease. 2020;11. doi:10.1177/2040622320936417
NO Ministerio de Sanidad (España)
NO Unión Europea
DS Docta Complutense
RD 7 abr 2025