RT Journal Article
T1 Effect of long-term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does
A1 Jordán-Rodríguez, Daniela
A1 Cáceres-Martín, Elisa
A1 Gómez-León, Alicia
A1 Rebollar, P. G.
A1 Lorenzo, P.L.
A1 García-García, R. M.
A1 Arias-Álvarez, M
A1 Vicente Carrillo, Alejandro
A1 Arias Álvarez, María
AB In	industrialized	farms,	rabbit	does	undergo	intensive	production	rhythms	which	overlap	lactation	and	gestation,	leading	to	a	high	energy	mobilization	and	increasing	oxidative	stress.	Accordingly,	we	hypothesize	that	administration	of	the	flavonoid	quercetin	(QUR)	may	improve	the	antioxidant	status	of	young	and	adult	rabbit	reproductive	females.	In	this	study,	the	effect	of	daily	oral	administration	of	300 mg/kg	QUR	for	8 weeks	was	assessed	on	the	antioxidant	profile	of	24	New	Zealand × Californian	rabbit	does,	assigned	to	4	experimental	groups:	rearing	young	(8–16 weeks	old)	and	adult	does	at	the	end	of	their	reproductive	life	(12–14 months	old,	with	at	least	3–4	reproductive	cycles)	treated	(YQ	and	AQ)	or	not	(YC	and	AC)	with	QUR,	respectively.	Plasma	glutathione	(GSH),	as	well	as	serum	superoxide	dismutase	(SOD)	and	malondialdehyde	(MDA)	were	measured	during	the	experimental	period.	To	assess	the	health	status	of	the	animals,	a	physical	examination	was	also	performed.	GSH	plasma	concentrations	were	significantly	higher	in	young	does	at	weeks	1	and	4,	but	not	at	week	8	of	the	experiment,	irrespectively	of	QUR	administration.	An	increase	in	GSH	plasma	concentration	was	observed	during	the	8-	week	experiment	in	both	AQ	and	AC	groups.	Furthermore,	QUR	administration	did	not	alter	either	SOD	or	MDA	serum	activity	and	concentration	in	any	group	during	the	experimental	period.	Physical	examination	revealed	no	differences	between	the	experimental	groups.	In	conclusion,	under	our	experimental	conditions,	QUR	did	not	modify	the	general	clinical	or	the	antioxidant	profile of young and adult reproductive rabbit females.
PB Wiley
SN 0936-6768
YR 2024
FD 2024-10-13
LK https://hdl.handle.net/20.500.14352/108989
UL https://hdl.handle.net/20.500.14352/108989
LA eng
NO 920249	UCM Groups
NO Ministerio de Ciencia e Innovación (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 7 abr 2025