RT Journal Article
T1 In vivo bioavailability of polyphenols from grape by-product extracts, and effect on lipemia of normocholesterolemic Wistar rats
A1 Olivero David, Raúl
A1 Ruiz Roso, María Belén
A1 Caporaso, Nicola
A1 Pérez-Olleros Conde, María Lourdes
A1 Heras Jiménez, Natalia De Las
A1 Lahera Julia, Vicente
A1 Ruiz-Roso Calvo De La Mora, Baltasar
AB BACKGROUND The direct use of phenolic extracts from grape by‐products can be useful to formulate functional food to improve consumers’ health. The use of phenolic extracts instead of pure polyphenols as an ingredient is relevant in this context. The current work studied the bioavailability and absorption of polyphenols from grape by‐product extracts and their health effect on cholesterolemia, by adding the extract (GE) to Wistar rats diet (50 g/kg) in vivo. RESULTS GE caused the appearance of (+)‐catechin, myricetin and quercetic acid in plasma and liver. (+)‐Catechin was the most abundant compound, with 6 μg/mL in plasma and 0.7 μg/mg protein in liver, while no phenolic compounds were detected in plasma or liver in the control group. Similarly, 3,4‐hydroxyphenylacetic (DOPAC), a major product of polyphenol digestion, was detected in the plasma, liver and urine of the GE‐group only. GE‐group had significantly lower cholesterol level and lower total cholesterol/HDL ratio in plasma. Total bile acid (TBA) content significantly increased in faecal matter after 24 h administration of the GE‐enriched diet. CONCLUSION Grape extract polyphenols are partially bioavailable and showed improvement in lipid metabolism. Thus, the results suggest that GE is promising as a functional ingredient in the prevention of hypercholesterolemia.
PB Wiley
SN 0022-5142
YR 2018
FD 2018-12
LK https://hdl.handle.net/20.500.14352/132093
UL https://hdl.handle.net/20.500.14352/132093
LA eng
NO Olivero-David R, Ruiz-Roso MB, Caporaso N, Perez-Olleros L, De Las Heras N, Lahera V, Ruiz-Roso B. In vivo bioavailability of polyphenols from grape by-product extracts, and effect on lipemia of normocholesterolemic Wistar rats. Journal of the Science of Food and Agriculture. 2018;98(15):5581–5590. https://doi.org/10.1002/jsfa.9100
NO Centro para el Desarrollo Tecnológico Industrial
NO Ministerio de Economía, Industria y Competitividad (España)
DS Docta Complutense
RD 18 mar 2026