RT Journal Article
T1 Light-induced ATP release from the lens
A1 Pintor Just, Jesús Jerónimo
AB The recent discovery of the photoreceptor melanopsin in lens epithelial cells has opened the possibility of modulating this protein by light stimulation. Experiments carried out on New Zealand white rabbits have demonstrated that the release of ATP from the lens to the aqueous humor can be reduced either when a yellow filter or a melanopsin antagonist is used. Compared to control (1.10 ± 0.15 μM ATP), the application of a yellow filter (λ465–480) reduced ATP in the aqueous humor 70%, while the melanopsin antagonist AA92593 reduced the presence of ATP 63% (n = 5), an effect which was also obtained with the PLC inhibitor U73122. These results indicate that when melanopsin is blocked either by the lack of light, a filter, or an antagonist, the extracellular presence of ATP is significantly reduced. This discovery may be relevant, on the one hand, because many ocular physiological processes are controlled by ATP and, on the other hand, because it is possible to stimulate ATP release with just light and without using any added substance.
PB Springer
SN 1573-9538
YR 2018
FD 2018-12-01
LK https://hdl.handle.net/20.500.14352/13028
UL https://hdl.handle.net/20.500.14352/13028
LA eng
NO Pintor Just, J. J. «Light-Induced ATP Release from the Lens». Purinergic Signalling, vol. 14, n.o 4, diciembre de 2018, pp. 499-504. DOI.org (Crossref), https://doi.org/10.1007/s11302-018-9626-3.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Ministerio de Sanidad (España)
NO Redes Temáticas de Investigación Cooperativa en Salud (España)
DS Docta Complutense
RD 11 abr 2025