RT Journal Article
T1 Choline acetyltransferase-immunoreactive neurons in the retina of adult and developing lampreys
A1 Pombal, Manuel Angel
A1 Abalo, Xesús Manoel
A1 Rodicio, María Celina
A1 Anadón, Ramón
A1 González Gallegos, Agustín
AB The presence of choline acetyltransferase-immunoreactive (ChATir) amacrine cells is reported for the first time in the retinas of three species of lamprey (Lampetra fluviatilis, Ichthyomyzon unicuspis, and Petromyzon marinus). In the three species, the ChATir cells were mainly distributed in the inner plexiform layer (IPL), which in lampreys extends from the inner nuclear layer (INL) to the inner limiting membrane. These cells had a bipolar, triangular or stellate appearance, and gave rise to processes coursing in the inner plexiform layer. In transforming lampreys, ChATir processes formed two asymmetrical inner and outer subplexuses in the inner plexiform layer, which is reminiscent of the distribution of processes of ChATir cells in the On and Off sublaminae reported in jawed vertebrates. The larval retina lacked ChAT immunoreactivity, and ChATir cells and processes appeared at early metamorphosis throughout the retina, exhibiting in late transforming stages an organization similar to that of adults. This first report of ChATir cells in the lamprey retina indicates that the appearance of cholinergic circuits in the retina of vertebrates occurred before the divergence of the agnathan and gnathostome lines.
PB Elsevier
SN 0006-8993
YR 2003
FD 2003
LK https://hdl.handle.net/20.500.14352/120468
UL https://hdl.handle.net/20.500.14352/120468
LA eng
NO Pombal, M. A., Abalo, X. M., Rodicio, M. C., Anadón, R., & González, A. (2003). Choline acetyltransferase-immunoreactive neurons in the retina of adult and developing lampreys. Brain Research, 993(1-2), 154-163. https://doi.org/10.1016/j.brainres.2003.09.005
NO This work was supported by grants from the Spanish Ministry of Science and Technology (BM2000-0283; PM99-0072; BOS2000-0559) and Xunta de Galicia (PGIDP99BI020002; PGIDT00PXI30112PR). X.M.A. received a predoctoral fellowship from the “Xunta de Galicia”.
NO Ministerio de Ciencia y Tecnología (España)
NO Xunta de Galicia
DS Docta Complutense
RD 18 mar 2026