RT Journal Article
T1 A novel zwitterionic bioceramic with dual antibacterial capability
A1 Colilla Nieto, Montserrat
A1 Martínez Carmona, Marina
A1 Sánchez-Salcedo, Sandra
A1 Ruiz González, María Luisa
A1 González Calbet, José María
A1 Vallet Regí, María Dulce Nombre
AB A novel zwitterionic SBA-15 type bioceramic with dual antibacterial capability has been synthesized. The cocondensation route has been employed to functionalize SBA-15 with primary and secondary amine groups. The resulting material exhibits textural and nanostructural properties comparable to those of pure silica SBA-15, as confirmed by XRD, HR-TEM and N2 adsorption porosimetry. The presence of –NH3 4/–SiO. and >NH2 4/–SiO. zwitterionic pairs on the material surface is evidenced by FTIR and 1H / 13C CP/MAS solid state NMR. The homogeneous distribution of this zwitterionic pairs agrees with the results derived from STEM-EDS studies. z-Potential measurements indicate that the zwitterionic nature of this material is preserved at the physiological pH of 7.4. In vitro bacterial assays using S. aureus demonstrate that the zwitterionic material is capable of inhibiting 99.9% of the bacterial adhesion compared to pure silica SBA-15. Moreover, cephalexin loading and delivery assays indicate that the zwitterionic sample is capable of releasing antibiotic molecules over long time periods. This dual antibacterial capability, i.e. antibiofouling and bactericidal, opens up promising expectations for the treatment of bone implant infections.
PB Royal Society of Chemistry
SN 2050-750X
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/34727
UL https://hdl.handle.net/20.500.14352/34727
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Agening Network of Excellence
DS Docta Complutense
RD 18 dic 2025