RT Journal Article
T1 Impact of probiotic treatment on clinical symptom reduction in schizophrenia: A systematic review and meta-analysis
A1 Romero Ferreiro, Verónica
A1 García Fernández, Lorena
A1 Romero, Carmen
A1 Fuente Del Rey, María Mónica De La
A1 Diaz del Cerro, Estefanía
A1 Scala, Mauro
A1 González Soltero, Rocío
A1 Álvarez Mon, Miguel Ángel
A1 Peñuelas Calvo, Inmaculada
A1 Rodríguez Jiménez, Roberto
AB Introduction. Recent research has identified gut microbiota dysbiosis as a potential contributing factor in schizophrenia, leading to growing interest in exploring probiotics as a complementary approach to traditional antipsychotic treatments. This study aims to systematically evaluate the current evidence on the efficacy of probiotics in improving clinical symptoms of schizophrenia, offering a novel perspective into their potential role as an adjunctive strategy. Methods. A systematic search was conducted to review randomized clinical trials, adhering to the PRISMA guidelines. A meta-analysis was also performed to assess the primary outcome, which was the impact of probiotic supplementation on clinical symptoms measured by the Positive and Negative Syndrome Scale (PANSS). Results. Of the 76 studies initially identified, 5 were finally included. Regarding the symptomatology measured through the PANSS total score, the average effect was significant after the probiotic supplementation (standardized mean difference [SMD] = −0.608, (95% CI -1.314; −0.047), p = .035. Conclusion. The synthesis of available data suggests that probiotic supplementation may effectively reduce clinical symptoms in schizophrenia. However, the limited number of studies prevents the formation of robust conclusions. Further clinical trials with more rigorous experimental designs are necessary before making definitive recommendations.
PB Elsevier
SN 0022-3956
YR 2025
FD 2025-01-24
LK https://hdl.handle.net/20.500.14352/118443
UL https://hdl.handle.net/20.500.14352/118443
LA eng
NO Romero-Ferreiro, V., García-Fernández, L., Romero, C., De la Fuente, M., Diaz-del Cerro, E., Scala, M., González-Soltero, R., Álvarez-Mon, M. A., Peñuelas-Calvo, I., & Rodriguez-Jimenez, R. (2025). Impact of probiotic treatment on clinical symptom reduction in schizophrenia: A systematic review and meta-analysis [Review of Impact of probiotic treatment on clinical symptom reduction in schizophrenia: A systematic review and meta-analysis]. Journal of Psychiatric Research, 182, 413-420. Elsevier Ltd. https://doi.org/10.1016/J.JPSYCHIRES.2025.01.050
NO This research was supported in part by the by the Instituto de Salud Carlos III (PI19/00766; Fondo de Investigaciones Sanitarias/FEDER), by the European Development Regional Fund ‘‘A way to achieve Europe’’ (ERDF), by Madrid Regional Government (R&D activities in Biomedicine P2022/BMD-7216 (AGES-CM 3-CM)) and Structural Funds of the European Union, by CIBERSAM-III.
NO Instituto de Salud Carlos III
NO European Commission
NO Comunidad de Madrid
DS Docta Complutense
RD 25 dic 2025