RT Journal Article
T1 The Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia
A1 Samaranch, Lluis et al.
A1 Pastor, Pau
A1 Barabash Bustelo, Ana
A1 Cabranes Díaz, José Antonio
A1 Marcos Dolado, Alberto
AB Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive impairment (MCI) and analyzed whether MAPT H1/H2 haplotypes and APOE ε4 polymorphisms accelerated the rate of progression from MCI to dementia. At the end of the study, 172 subjects remained cognitively stable, whereas 147 progressed to dementia. APOE ε4 and MAPT H1/H1 were independently associated with an increased rate of progression to dementia in the combined sample. Cox regression models of the combined MCI sample showed that MAPT H1/H1 carriers had an increased rate of progression to dementia compared with non carriers (Hazard Ratio =1.45; 95% CI=1.04-2.02; p=0.028) and time-to-progression was shortened by 1.37 years. APOE ε4 allele also accelerated progression to dementia (Hazard Ratio=1.47; 95% CI= 1.06-2.04; p=0.020) and reduced the time-to-progression by 0.87 years. Additionally, MAPT H1/H1 genotype and APOE ε4 allele had an additive effect in progression to dementia, increasing progression rate to dementia (Hazard Ratio=2.24, 95% CI =1.40-3.58; p=0.001) and shortening time-to-progression to dementia by 2.92 years. Similar results were obtained when only considering progression to AD-type dementia. Our results suggest that both MAPT H1/H1 genotype and APOE ε4 allele lead to a more rapid progression to dementia among MCI subjects, probably mediating an increased rate of amyloid-β and tau brain deposition.
PB IOS PRESS
SN 1875-8908
SN 1387-2877
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/116420
UL https://hdl.handle.net/20.500.14352/116420
LA eng
NO Samaranch L, Cervantes S, Barabash A, Alonso A, Cabranes JA, Lamet I, et al. The Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia. JAD 2011;22:1065–71. https://doi.org/10.3233/JAD-2010-101011
NO Minsiterio de Ciencia, Innovación y Universidades-Instituto de Salud Carlos III
NO Departmento de Salud del Gobierno de Navarra.
DS Docta Complutense
RD 22 abr 2025