RT Journal Article
T1 Role of nerve growth factor in the reproductive physiology of female rabbits: A review
A1 Rebollar, P.G.
A1 García García, Rosa María
A1 Arias Álvarez, María
A1 Sánchez Rodríguez, Ana
A1 Lorenzo González, Pedro Luis
AB Rabbit does are reflex ovulators such that coitus is needed to release GnRH and elicit the LH surge that triggers the ovulation of mature oocytes. However, the mechanisms eliciting ovulation in this species remain unclear. One of the most promising recently discovered candidates with a role in female reproductive physiology is nerve growth factor beta (b-NGF). This neurotrophin and its high-affinity receptor TrkA and low affinity receptor p75, is present in all compartments of the ovary, oviduct and uterus suggesting a physiologic role in ovarian folliculogenesis, steroidogenesis, ovulation, luteogenesis and embryo development. Besides, evidence exists that b-NGF found in seminal plasma could exert a modulatory role in the female hypothalamus-pituitary-ovarian axis contributing to the adrenergic and cholinergic neuronal stimulus of GnRH neurons in an endocrine manner during natural mating. Probably, the paracrine and local roles of the neurotrophin in steroidogenesis and ovulation reinforce the neuroendocrine pathway that leads to ovulation. This review updates knowledge of the role of b-NGF in rabbit reproduction, including its possible contribution to the mechanisms of action that induce ovulation, and discusses perspectives for the future applications of this neurotrophin on rabbit farms.
PB Elsevier
SN 0093-691X
YR 2020
FD 2020-01-30
LK https://hdl.handle.net/20.500.14352/102775
UL https://hdl.handle.net/20.500.14352/102775
LA eng
DS Docta Complutense
RD 17 ago 2024