%0 Journal Article
%A Luna Costales, Amparo
%A Esteban Arderíus, Pablo
%A Herrera García, Fernando
%A San Martín Loubet, Daniel
%A Almendros Requena, Pedro
%T Regioselectivity switch based on the stoichiometry: stereoselective synthesis of trisubstituted vinyl epoxides by Cu-catalyzed 3-exo-trig cyclization of α-allenols
%D 2022
%@ ISSN:1615-4150
%U https://hdl.handle.net/20.500.14352/114881
%X Typical transition metal-catalyzed oxycyclization of allenols takes place at the terminal allene carbon via a 5-endo path and forms dihydrofurans. A copper-catalyzed protocol brought about a reversed regioselectivity, generating a series of trisubstituted epoxides through a 3-exo-cyclization/sulfonylation cascade. The current stoichiometry control of regioselectivity may open singular opportunities in chemical transformations.
%~