RT Journal Article
T1 Regioselectivity switch based on the stoichiometry: stereoselective synthesis of trisubstituted vinyl epoxides by Cu-catalyzed 3-exo-trig cyclization of α-allenols
A1 Luna Costales, Amparo
A1 Esteban Arderíus, Pablo
A1 Herrera García, Fernando
A1 San Martín Loubet, Daniel
A1 Almendros Requena, Pedro
AB Typical transition metal-catalyzed oxycyclization of allenols takes place at the terminal allene carbon via a 5-endo path and forms dihydrofurans. A copper-catalyzed protocol brought about a reversed regioselectivity, generating a series of trisubstituted epoxides through a 3-exo-cyclization/sulfonylation cascade. The current stoichiometry control of regioselectivity may open singular opportunities in chemical transformations.
PB Wiley-VCH
SN ISSN:1615-4150
YR 2022
FD 2022-08-10
LK https://hdl.handle.net/20.500.14352/114881
UL https://hdl.handle.net/20.500.14352/114881
LA eng
NO Esteban P, Herrera F, San Martín D, Luna A, Almendros P. Regioselectivity Switch Based on the Stoichiometry: Stereoselective Synthesis of Trisubstituted Vinyl Epoxides by Cu‐Catalyzed 3‐exo‐trig Cyclization of α‐Allenols. Advanced Synthesis & Catalysis. 2022, 364, 3289–3294.
NO Ministerio de Ciencia e Innovación (España)
NO Agencia Estatal de Investigación (España)
NO European Commission
DS Docta Complutense
RD 6 abr 2025