RT Journal Article
T1 Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects
A1 Garcimartín Álvarez, Alba
A1 Merino Martín, José Joaquín
A1 González Prieto, María Del Pilar
A1 Sánchez Reus, María Isabel
A1 Sánchez Muniz, Francisco José
A1 Bastida Codina, Sara
A1 Benedí González, Juana María
AB Background: Hydrogen peroxide (H2O2) is a toxic agent that induces oxidative stress and cell death. Silicon (Si) is a biological element involved in limiting aluminium (Al) absorption with possible preventive effects in Alzheimer's disease. However, Si has not yet been associated with other neuroprotective mechanisms.Methods: The present experiments evaluated in the SH-SY5Y human neuroblastoma cell line the possible role of different Si G5 (50-1000 ng/mL) concentrations in preventing cellular death induced by H2O2 (400 μM, 24 hours).Results: Our findings showed that H2O2 promoted cell death in the human SH-SY5Y cell cultures and this could be prevented by Si treatment. The loss in cell viability mediated by H2O2 was due to an apoptotic and necrotic process. Apoptotic death was incurred by regulating caspase-8 activity in the extrinsic pathway. The apoptotic and necrotic cell death induced by H2O2 was almost totally reversed by Si (50-500 ng/mL), indicating that it down-regulates both processes in H2O2 treated cells.Conclusions: According to our data, Si is able to increase SH-SY5Y cell survival throughout partially blocking cellular damage related to oxidative stress through a mechanism that would affect H2O2/ROS elimination.
PB Springer Nature
SN 1472-6882
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/116409
UL https://hdl.handle.net/20.500.14352/116409
LA eng
NO Garcimartín, A., Merino, J.J., González, M.P. et al. Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects. BMC Complement Altern Med 14, 384 (2014). https://doi.org/10.1186/1472-6882-14-384
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 9 abr 2025