RT Journal Article
T1 Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems
A1 Dumontel, Bianca
A1 Jiménez-Jiménez, Carla
A1 Vallet Regí, María Dulce Nombre
A1 Manzano García, Miguel
AB In recent years, there has been a breakthrough in the integration of artificial nanoplatforms with natural biomaterials for the development of more efficient drug delivery systems. The formulation of bioinspired nanosystems, combining the benefits of synthetic nanoparticles with the natural features of biological materials, provides an efficient strategy to improve nanoparticle circulation time, biocompatibility and specificity towardtargeted tissues. Among others biological materials, extracellular vesicles (EVs), membranous structures secreted by many types of cells composed by a protein rich lipid bilayer, have shown a great potential as drug delivery systems themselves and in combination with artificial nanoparticles. The reason for such interest relays on their natural properties, such as overcoming several biological barriers or migration towards specific tissues. Here, we propose the use of mesoporous silica nanoparticles (MSNs) as efficient and versatile nanocarriers in combination with tumor derived extracellular vesicles (EVs) for the development of selective drug delivery systems. The hybrid nanosystems demonstrated selective cellular internalization in parent cells, indicating that the EV targeting capabilities were efficiently transferred to MSNs by the developed coating strategy. As a result, EVs-coated MSNs provided an enhanced and selective intracellular accumulation of doxorubicin and a specific cytotoxic activity against targeted cancer cells, revealing these hybrid nanosystems as promising candidates for the development of targeted treatments.
PB Elsevier
SN 2590-0064
YR 2023
FD 2023-12
LK https://hdl.handle.net/20.500.14352/105549
UL https://hdl.handle.net/20.500.14352/105549
LA eng
NO Bianca Dumontel, Carla Jiménez-Jiménez, María Vallet-Regí, Miguel Manzano, Bioinspired extracellular vesicle-coated silica nanoparticles as selective delivery systems, Materials Today Bio, Volume 23, 2023, 100850
NO Ministerio de Ciencia e Innovacion (España)
NO European Commission
NO Comunidad de Madrid
DS Docta Complutense
RD 29 jul 2024