RT Journal Article
T1 Rationale and design of the optical coherence tomography observation of pulmonary ultra-structural changes in heart failure (OCTOPUS-CHF) study
A1 Ortiz Bautista, Carlos
A1 Gutiérrez Ibañes, Enrique
A1 García Cosío, María Dolores
A1 Calviño-Santos, Ramón
A1 Gómez Bueno, Manuel
A1 Mirabet Pérez, Sonia
A1 Gómez Hospital, Joan Antoni
A1 Lambert Rodríguez, José Luis
A1 Garrido Bravo, Iris Paula
A1 Fuente Galán, Luis de la
A1 Mombiela, Teresa
A1 Martínez Solano, Jorge
A1 Martínez Sellés, Manuel
A1 Martínez-Sellés D Oliveira Soares, Manuel
AB Background: The assessment of vascular remodeling using optical coherence tomography (OCT) has been previously described in some types of pulmonary hypertension. However, evidence about its feasibility and clinical utility for evaluation of pulmonary arterial vasculopathy in advanced heart failure (HF) is scarce. Optical Coherence Tomography Observation of Pulmonary Ultra-Structural Changes in Heart Failure (OCTOPUS-CHF) study is designed to study the correlation between OCT-morphometric parameters and hemodynamic data measured or derived from right heart catheterization (RHC). Methods: OCTOPUS-CHF is an observational, prospective, multicentre study aiming to recruit 100 patients with advanced HF referred for heart transplantation (HTx) evaluation. As part of such evaluation, all patients will undergo RHC in order to rule out severe pulmonary hypertension. After RHC, a Dragonfly™ OPTIS™ imaging catheter will be used to perform OCT evaluation of a right-lower-lobe pulmonary artery with a luminal diameter ≤ 5 mm. The primary objective is to study the correlation of OCT parameters with hemodynamic RHC data. The secondary objective is to determine if OCT parameters improve prognostic stratification. Conclusions: The OCTOPUS-CHF studywill investigate the feasibility and clinical utility of pulmonary arterial vasculopathy evaluation with OCT in advanced HF patients and its correlation with hemodynamic RHC data. The ability of OCT-morphometric parameters to improve prognostic stratification will also be tested.
PB Elsevier
YR 2019
FD 2019-06-26
LK https://hdl.handle.net/20.500.14352/117559
UL https://hdl.handle.net/20.500.14352/117559
LA eng
NO Ortiz-Bautista C, Gutiérrez-Ibañes E, García-Cosío MD, Calviño-Santos R, Gómez-Bueno M, Mirabet-Pérez S, Gómez-Hospital JA, Lambert-Rodríguez JL, Garrido-Bravo IP, de la Fuente Galán L, Mombiela T, Martínez-Solano J, Martínez-Sellés M. Rationale and design of the optical coherence tomography observation of pulmonary ultra-structural changes in heart failure (OCTOPUS-CHF) study. Int J Cardiol. 2020 Jan 15;299:296-300.
DS Docta Complutense
RD 5 abr 2025