RT Journal Article
T1 c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease
A1 Zheng, Kang
A1 Cubero Palero, Francisco Javier
A1 Nevzorova, Yulia
AB Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.
PB MDPI
SN 2073-4425
YR 2017
FD 2017-04-19
LK https://hdl.handle.net/20.500.14352/19137
UL https://hdl.handle.net/20.500.14352/19137
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia e Innovación (MICINN)
NO German Research Foundation
DS Docta Complutense
RD 13 may 2025