RT Journal Article
T1 Trends in Anaphylaxis Hospitalizations among Adults in Spain and Their Relationship with Asthma-Analysis of Hospital Discharge data from 2016 to 2021
A1 Caballero-Segura, Francisco J,
A1 Zamorano-Leon, José J.
A1 Miguel-Díez, Javier de
A1 Cuadrado Corrales, María Natividad
A1 Jiménez García, Rodrigo
A1 López De Andrés, Ana Isabel
A1 Carabantes Alarcón, David
A1 Carricondo Orejana, Francisco Javier
A1 Romero Gómez, Bárbara
A1 Miguel Díez, Javier De
A2 MDPI, 
AB (1) Background: Anaphylaxis is a rapid-onset, life-threatening hypersensitivity reaction. This study explores the epidemiological trends and clinical outcomes of adult patients with and without asthma hospitalized for anaphylaxis in Spain from 2016 to 2021. (2) Methods: Data from the Spanish National Hospital Discharge Database (RAE-CMBD) were analyzed. We stratified patients with anaphylaxis based on their asthma diagnosis and evaluated various comorbidities and clinical outcomes. Propensity score matching was used to match confounders. (3) Results: The total number of hospitalizations for anaphylaxis remained stable, with a decrease in 2020 probably due to the COVID-19 pandemic. Drug-induced anaphylaxis increased, in addition to being the main triggering factor. Asthma prevalence among those admitted for anaphylaxis emerged from 7.63% to 10.69%, with a higher frequency of respiratory failure and need for mechanical ventilation in this group; despite this, ICU admissions and in-hospital mortality did not differ significantly between asthmatics and non-asthmatics. Asthma was also not a risk factor for severe anaphylaxis. Multivariable analysis identified advanced age, ischemic heart disease, acute respiratory failure, and invasive mechanical ventilation as factors associated with severe anaphylaxis. (4) Conclusions: This study provides valuable information on the complexity of anaphylaxis, its relationship with asthma, and factors influencing its severity. Overall, clinical outcomes did not differ significantly in asthmatic patients compared to non-asthmatic patients, although asthmatic patients had more respiratory complications. Further research is necessary to delve deeper into the multifactorial nature of anaphylaxis and its implications in clinical practice.
PB MDPI
YR 2023
FD 2023-12
LK https://hdl.handle.net/20.500.14352/99676
UL https://hdl.handle.net/20.500.14352/99676
LA eng
NO Caballero-Segura FJ, Cuadrado-Corrales N, Jimenez-Garcia R, Lopez-de-Andres A, Carabantes-Alarcon D, Zamorano-Leon JJ, Carricondo F, Romero-Gomez B, De- Miguel-Díez J. Trends in Anaphylaxis Hospitalizations among Adults in Spain and Their Relationship with Asthma-Analysis of Hospital Discharge data from 2016 to 2021. Healthcare (Basel). 2023 Nov 22;11(23):3016.
NO Madrid Government under the Multiannual Agreement with Universidad Complutense de Madrid in the line Excellence Programme for university teaching staff, in the context of the V PRICIT and by Universidad Complutense de Madrid, Grupo de Investigación en Epidemiología de las Enfermedades Crónicas de Alta Prevalencia en España GEPIECAP
DS Docta Complutense
RD 18 jul 2024