%0 Journal Article
%A Cabal, Belén
%A Alou Cervera, Luis
%A Cafini, Fabio
%A Couceiro, Ramiro
%A Sevillano Fernández, David
%A Esteban Tejeda, Leticia
%A Guitián, Francisco
%A Torrecillas, Ramón
%A Moya, José S.
%T A New Biocompatible and Antibacterial Phosphate Free Glass-Ceramic for Medical Applications
%D 2014
%@ 2045-2322
%U https://hdl.handle.net/20.500.14352/106086
%X In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.
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