RT null
T1 Timing the juvenile-adult neurohormonal transition: functions and evolution
A1 Barredo, Celia G.
A1 Gil-Marti, Beatriz
A1 Deveci, Derya
A1 Romero, Nuria M.
A1 Martín Castro, Francisco Antonio
AB Puberty and metamorphosis are two major developmental transitions linked to the reproductive maturation. In mammals and vertebrates, the central brain acts as a gatekeeper, timing the developmental transition through the activation of a neuroendocrine circuitry. In addition to reproduction, these neuroendocrine axes and the sustaining genetic network play additional roles in metabolism, sleep and behavior. Although neurohormonal axes regulating juvenile-adult transition have been classically considered the result of convergent evolution (i.e., analogous) between mammals and insects, recent findings challenge this idea, suggesting that at least some neuroendocrine circuits might be present in the common bilaterian ancestor Urbilateria. The initial signaling pathways that trigger the transition in different species appear to be of a single evolutionary origin and, consequently, many of the resulting functions are conserved with a few other molecular players being co-opted during evolution.
PB Frontiers
SN 1664-2392
YR 2021
FD 2021-02
LK https://hdl.handle.net/20.500.14352/128266
UL https://hdl.handle.net/20.500.14352/128266
LA eng
NO Barredo CG, Gil-Marti B, Deveci D, Romero NM and Martin FA (2021) Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution. Front. Endocrinol. 11:602285. doi: 10.3389/fendo.2020.602285
NO This work was supported by MICINN (Grant number PGC2018-094630-B-I00 to FM), Comunidad de Madrid (CB was a recipient of “Ayuda de Garantía Juvenil para la contratación de investigadores predoctorales” fellowship, grant number PEJD-2019-PRE/BMD-15940), CSIC (BG-M was a recipient of a JAE intro fellowship, grant number JAEINT_19_00602), Inserm (ATIP-Avenir program to NR) and the French National Research Agency -ANR- (“Investments for the Future” programs LABEX SIGNALIFE ANR-11-LABX-0028 and IDEX UCAJedi ANR-15-IDEX-01 to NR). FM is a recipient of a RyC-2014-14961 contract. MEFP (CGB is a recipient of a FPU predoctoral fellowship, grant number FPU19/04449), UAM (BG-M is a recipient of a predoctoral fellowship, grant number SFPI/2020/00878).
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
NO Consejo Superior de Investigaciones Científicas (España)
NO Institut national de la santé et de la recherche médicale (Francia)
NO Centre national de la recherche scientifique (Francia)
NO Universidad Autónoma de Madrid
DS Docta Complutense
RD 25 feb 2026