RT Journal Article
T1 Pro-/Antiinflammatory Dysregulation in Early Psychosis: Results from a 1-Year Follow-Up Study
A1 Moreno Ruiz, María del Carmen
A1 García Bueno, Borja
A1 Bioque M, 
A1 Mac-Dowell Mata, Karina Soledad
A1 Santabárbara J, 
A1 Martínez-Cengotitabengoa M, 
A1 Sáiz PA, 
A1 Berrocoso E, 
A1 Gassó P, 
A1 Fe Barcones M, 
A1 González-Pinto A, 
A1 Parellada Redondo, María José
A1 Bobes J, 
A1 Micó JA, 
A1 Bernardo M, 
A1 Leza Cerro, Juan Carlos
A1 FLAMM-PEPs study, 
AB Background:Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to identify potential risk/protective factors and associations with symptom severity.Methods:Eighty-five subjects were followed during 12 months and the determination of the same pro-/antiinflammatory mediators was carried out in plasma and peripheral blood mononuclear cells. Multivariate logistic regression analyses were used to identify risk/protective factors. Multiple linear regression models were performed to detect the change of each biological marker during follow-up in relation to clinical characteristics and confounding factors.Results:This study suggests a more severe systemic pro-/antiinflammatory deregulation than in earlier pathological stages in first psychotic episode, because not only were intracellular components of the inflammatory response increased but also the majority of soluble elements. Nitrite plasma levels and cyclooxygenase-2 expression in peripheral blood mononuclear cells are reliable potential risk factors and 15d-prostaglandin-J2 plasma levels a protection biomarker. An interesting relationship exists between antipsychotic dose and the levels of prostaglandin-E2 (inverse) and 15d-prostaglandin-J2 (direct). An inverse relationship between the Global Assessment of Functioning scale and lipid peroxidation is also present.Conclusions:Summing up, pro-/antiinflammatory mediators can be used as risk/protection biomarkers. The inverse association between oxidative/nitrosative damage and the Global Assessment of Functioning scale, and the possibility that one of the targets of antipsychotics could be the restoration of the pro-/antiinflammatory balance support the use of antiinflammatory drugs as coadjuvant to antipsychotics.
PB Cambridge University Press
SN 1469-5111
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/116256
UL https://hdl.handle.net/20.500.14352/116256
LA eng
NO García-Bueno B, Bioque M, MacDowell KS, Santabárbara J, Martínez-Cengotitabengoa M, Moreno C, Sáiz PA, Berrocoso E, Gassó P, Fe Barcones M, González-Pinto A, Parellada M, Bobes J, Micó JA, Bernardo M, Leza JC; FLAMM-PEPs study, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study. Int J Neuropsychopharmacol. 2014 Oct 31;18(2):pyu037. doi: 10.1093/ijnp/pyu037
NO CIBERSAM Intramural Projects 2010 (P02): Flamm-PEPs
NO Spanish Ministry of Economy and Competiveness
NO Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias
DS Docta Complutense
RD 9 abr 2025