RT Journal Article
T1 Efficacy of Ologen matrix implant in Ahmed Glaucoma Valve Implantation
A1 Sastre Ibáñez, Marina
A1 Cabarga del Nozal, Carmen
A1 Canut Jordana, María Isabel
A1 Pérez Bartolomé, Francisco
A1 Urcelay Segura, José Luis
A1 Cordero Ros, Rosa María
A1 García Feijoo, Julián
A1 Martínez De La Casa Fernández-Borrella, José María
AB To determine the efficacy and safety of the Ologen collagen matrix adjunctive to Ahmed valve surgery. A randomized prospective multicentre clinical trial involving 58 patients that were followed for one year. Conventional surgery with Ahmed valve was performed in 31 eyes (Control group/CG) and in 27 Ologen (Ologen group/OG) was placed over the valve’s plate. Baseline data: age, corneal thickness, intraocular pressure(IOP) and antiglaucoma medications.Postoperative data (days 1, 7 and months 1, 3, 6 and 12): IOP, antiglaucoma medications, visual acuity and complications were recorded. Frequency of hypertensive phase, complete and qualified success and survival rate were studied. No differences were found between CG and OG in the baseline data. The only difference between groups was a significantly lower IOP at day 1. No other differences were found in the follow-up between groups. Hypertensive phase (56%CG and 55%OG, p = 0,947), complete success 28,6%CG and 30,4%OG (p = 0,88) and qualified success 96,4% and 95,9%(p = 0,794). Survival rates at 1 year were 76,7%(CG) and 69,2%(OG)(p = 0,531). 38,7% of patients in the CG suffered some complication during follow-up and 61,5% in OG(p = 0,086). Ologen does not increase safety or efficacy in Ahmed valve surgery at one-year follow-up. This is the first study that shows no benefit of Ologen adjunctive to this surgery.
PB Nature Publishing
SN 2045-2322
YR 2019
FD 2019-02-28
LK https://hdl.handle.net/20.500.14352/13235
UL https://hdl.handle.net/20.500.14352/13235
LA eng
NO Sastre Ibáñez, M., Cabarga del Nozal, C., Canut Jordana, M. I. et al. «Efficacy of Ologen Matrix Implant in Ahmed Glaucoma Valve Implantation». Scientific Reports, vol. 9, n.o 1, febrero de 2019, p. 3178. DOI.org (Crossref), https://doi.org/10.1038/s41598-019-38656-x.
NO Universidad Complutense de Madrid
NO Instituto de Salud Carlos III
NO Red Temática de Investigación Cooperativa en Salud
NO Grupo de investigación en terapias y patologías del sistema visual
DS Docta Complutense
RD 17 abr 2025