RT Journal Article
T1 The Gastrointestinal Tract Is Pinpointed as a Reservoir of Candida albicans, Candida parapsilosis, and Candida tropicalis Genotypes Found in Blood and Intra-Abdominal Samples
A1 Mesquida Marcos, Aina Catalina
A1 Machado Vilchez, Marina
A1 Dávila Cherres, Lorena
A1 Vicente, Teresa
A1 Sánchez Carrillo, Carlos
A1 Alcalá Hernández, Luis
A1 Reigadas Ramírez, Elena Manuela
A1 Muñoz García, Patricia Carmen
A1 Guinea Ortega, Jesús
A1 Escribano Martos, Pilar
AB Background: Candida spp., as part of the microbiota, can colonise the gastrointestinal tract. We hypothesised that genotyping Candida spp. isolates from the gastrointestinal tract could help spot genotypes able to cause invasive infections. Materials/methods: A total of 816 isolates of C. albicans (n = 595), C. parapsilosis (n = 118), and C. tropicalis (n = 103) from rectal swabs (n = 754 patients) were studied. Genotyping was conducted using species-specific microsatellite markers. Rectal swab genotypes were compared with previously studied blood (n = 814) and intra-abdominal (n = 202) genotypes. Results: A total of 36/754 patients had the same Candida spp. isolated from blood cultures, intra-abdominal samples, or both; these patients had candidemia (n = 18), intra-abdominal candidiasis (n = 11), both clinical forms (n = 1), and non-significant isolation (n = 6). Genotypes matching the rectal swab and their blood cultures (84.2%) or their intra-abdominal samples (92.3%) were found in most of the significant patients. We detected 656 genotypes from rectal swabs, 88.4% of which were singletons and 11.6% were clusters. Of these 656 rectal swab genotypes, 94 (14.3%) were also detected in blood cultures and 34 (5.2%) in intra-abdominal samples. Of the rectal swab clusters, 62.7% were previously defined as a widespread genotype. Conclusions: Our study pinpoints the gastrointestinal tract as a potential reservoir of potentially invasive Candida spp. genotypes.
PB MDPI
YR 2023
FD 2023-07-06
LK https://hdl.handle.net/20.500.14352/104916
UL https://hdl.handle.net/20.500.14352/104916
LA eng
NO Mesquida A, Machado M, Dávila-Cherres L, Vicente T, Sánchez-Carrillo C, Alcalá L, et al. The Gastrointestinal Tract Is Pinpointed as a Reservoir of Candida albicans, Candida parapsilosis, and Candida tropicalis Genotypes Found in Blood and Intra-Abdominal Samples. JoF 2023;9:732. https://doi.org/10.3390/jof9070732.
NO 2023 Descuento MDPI
NO Fondo de Investigación Sanitaria
NO Instituto de Salud Carlos III
NO Federación Española de Enfermedades Raras
NO Hospital Gregorio Marañón
DS Docta Complutense
RD 6 abr 2025