RT Journal Article
T1 Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses
A1 Khalafiyan, Anis
A1 Fadaie, Mahmood
A1 Fatemeh Khara, 
A1 Zarrabi, Ali
A1 Moghadam, Fariborz
A1 Khanahmad, Hossein
A1 Cordani, Marco
A1 Boshtam, Maryam
AB Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in regulating eukaryotic cellular processes and maintaining homeostasis, making it physiologically important even under normal conditions. Cellular mechanisms involving autophagy include the response to nutrient deprivation, intracellular quality control, early development, and cell differentiation. Despite its established health significance, the role of autophagy in cancer and other diseases remains complex and not fully understood. A comprehensive understanding of autophagy is crucial to facilitate the development of novel therapies and drugs that can protect and improve human health. High-throughput technologies, such as single-cell RNA sequencing (scRNA-seq), have enabled researchers to study transcriptional landscapes at single-cell resolution, significantly advancing our knowledge of autophagy pathways across diverse physiological and pathological contexts. This review discusses the latest advances in scRNA-seq for autophagy research and highlights its potential in the molecular characterization of various diseases.
PB Elsevier
SN 1359-6446
YR 2024
FD 2024-12
LK https://hdl.handle.net/20.500.14352/116799
UL https://hdl.handle.net/20.500.14352/116799
LA eng
NO Khalafiyan, A., Fadaie, M., Khara, F., Zarrabi, A., Moghadam, F., Khanahmad, H., Cordani, M., & Boshtam, M. (2024). Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses [Review of Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses]. Drug Discovery Today, 29(12). Elsevier Ltd. https://doi.org/10.1016/J.DRUDIS.2024.104224
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
DS Docta Complutense
RD 7 abr 2025