%0 Journal Article
%A De Barrio, M
%A Fuentes, V
%A Tornero, P
%A Sánchez, I
%A Herrero, T
%A Zubeldia Ortuño, José Manuel
%T Anaphylaxis to Oral Iron Salts. Desensitization Protocol for Tolerance Induction
%D 2008
%U https://hdl.handle.net/20.500.14352/115660
%X Allergies to iron salts are seldom reported. We studied a patient with iron-deficiency anemia who had suffered anaphylactic reactions caused by oral iron salts. An allergy study was performed using single-blind, placebo-controlled oral challenge and skin tests with various iron salts as well as excipients in commercial formulations. Oral challenges were positive for 2 of the commercial formulations of iron salts. Intradermal tests with ferrous sulphate and ferrous lactate also showed positive results. All of the cutaneous tests using the excipients were negative. A desensitization protocol was designed which enabled us to readminister ferrous sulphate, although antihistamines were necessary to guarantee good tolerance to iron salts. We report a patient with allergy to iron salts, positive skin tests, and positive controlled challenge. We highlight the desensitization protocol designed to complete the therapeutic management of the anemia.
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