RT Journal Article
T1 Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
A1 Galluzzi, Lorenzo
A1 Levine, Beth
A1 Green, Douglas R.
A1 Kroemer, Guido
AB Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.
PB Springer Nature
SN 1474-1776
YR 2017
FD 2017-05
LK https://hdl.handle.net/20.500.14352/129054
UL https://hdl.handle.net/20.500.14352/129054
LA eng
NO Galluzzi L, Bravo-San Pedro JM, Levine B, Green DR, Kroemer G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2017 Jul;16(7):487–511.
DS Docta Complutense
RD 30 mar 2026