RT Journal Article
T1 Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy
A1 Fernández Albarral, José Antonio
A1 García Martín, Elena Salobrar
A1 Matamoros, José A.
A1 Fernández Mendivil, Cristina
A1 Sastre, Eric, del
A1 Chen, Leijing
A1 Hoz Montañana, María Rosa de
A1 López Cuenca, Inés
A1 Sánchez Puebla, Lídia
A1 Ramirez Sebastian, Jose Manuel
A1 Salazar Corral, Juan José
A1 García López, Manuela (Manuela G. López)
A1 Ramírez Sebastián, Ana Isabel
AB Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia, causing iron accumulation, neuroinflammation, and neurodegeneration. The retina is an organ that can be readily accessed and can reflect changes that occur in the brain. In this context, we evaluated how the lack of microglial HO-1, using mice that do not express HO-1 in microglia (HMO-KO), impacts retinal macro and microgliosis of aged subjects (18 months old mice) subjected to tauopathy by intrahippocampal delivery of AAV-hTauP301L (TAU). Our results show that although tauopathy, measured as anti-TAUY9 and anti-AT8 positive immunostaining, was not observed in the retina of WT-TAU or HMO-KO+TAU mice, a morphometric study of retinal microglia and macroglia showed significant retinal changes in the TAU group compared to the WT group, such as: (i) increased number of activated microglia, (ii) retraction of microglial processes, (iii) increased number of CD68+ microglia, and (iv) increased retinal area occupied by GFAP (AROA) and C3 (AROC3). This retinal inflammatory profile was reduced in HMO-KO+TAU mice. Conclusion: Reduction of microglial HO-1 could be beneficial to prevent tauopathy-induced neuroinflammation.
PB MDPI
SN 2076-3921
YR 2022
FD 2022-10-30
LK https://hdl.handle.net/20.500.14352/72797
UL https://hdl.handle.net/20.500.14352/72797
LA eng
NO Fernández-Albarral, J. A., García Martín, E. S., Matamoros, J. A. et al. «Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy». Antioxidants, vol. 11, n.o 11, octubre de 2022, p. 2151. DOI.org (Crossref), https://doi.org/10.3390/antiox11112151.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 17 jul 2024