RT Journal Article
T1 Alteration and reorganization of functional networks: a new perspective in brain injury study
A1 Castellanos, Nazareth
A1 Bajo Bretón, Ricardo
A1 Cuesta Prieto, Pablo
A1 Villacorta Atienza, José Antonio
A1 Paul Lapedriza, Nuria Ascensión
A1 García Prieto, Juan
A1 Del Pozo, Fernando
A1 Maestu Unturbe, Fernando
AB Plasticity is the mechanism underlying the brain’s potential capability to compensate injury. Recently several studies have shown how functional connections among the brain areas are severely altered by brain injury and plasticity leading to a reorganization of the networks. This new approach studies the impact of brain injury by means of alteration of functional interactions. The concept of functional connectivity refers to the statistical interdependen- cies between physiological time series simultaneously recorded in various areas of the brain and it could be an essential tool for brain functional studies, being its deviation from healthy reference an indicator for damage. In this article, we review studies investigating functional connectivity changes after brain injury and subsequent recovery, providing an accessible introduction to common mathematical methods to infer functional connectivity, exploring their capabilities, future perspectives, and clinical uses in brain injury studies.
PB Frontiers
SN 1662-5161
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/97428
UL https://hdl.handle.net/20.500.14352/97428
LA eng
NO Castellanos NP, Bajo R, Cuesta P, Villacorta-Atienza JA, Paúl N, Garcia-Prieto J, del-Pozo F and Maestú F (2011) Alteration and reorganization of functional networks: a new perspective in brain injury study. Front. Hum. Neurosci. 5:90. doi: 10.3389/fnhum.2011.00090
NO Received: 28 October 2010; Accepted: 11 August 2011; Published online: 21 September 2011.© 2011 Castellanos, Bajo, Cuesta, Villacorta-Atienza, Paúl, Garcia-Prieto, del-Pozo and Maestú. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
DS Docta Complutense
RD 6 abr 2025