RT Journal Article
T1 Prevalence of Associated Extraoral Symptoms and Comorbidities in Burning Mouth Syndrome Patients: A Systematic Review
A1 Gonçalves de Paiva, Joao Paulo
A1 Mariano Pedroso, Caique
A1 López-Pintor Muñoz, Rosa María
A1 Chmieliauskaite, Milda
A1 Villa, Alessandro
A1 Jorge, Jacks
A1 Santos-Silva, Alan Roger
AB Objective: Patients with burning mouth syndrome (BMS) suffer from oral pain in the absence of oral lesions. Although less frequently, they may also experience extraoral symptoms that are not readily apparent to clinicians. This study aimed to systematically assess the prevalence of associated extraoral symptoms and comorbid disorders in BMS patients.Methods: Comprehensive searches were performed in five electronic databases (PubMed, Web of Science, Scopus, Embase, and LILACS). Observational studies that reported extraoral symptoms in primary BMS patients were included. The collected data were analyzed descriptively. The quality assessment of the included studies was conducted using the Joanna Briggs Institute tools.Results: We included 22 studies encompassing 2786 BMS patients. Most patients were female (n = 2138; 76.7%). BMS-associated extraoral symptoms and comorbidities disorders included sleep disturbances (71.8%), anxiety (65.7%), depression (60.6%), alexithymia (6.1%), tinnitus (5.9%), low back pain (45.3%), and headache (4.4%). Fifteen studies were classified as low risk, six as moderate risk, and one as high risk of bias.Conclusions: BMS patients experience associated extraoral symptoms and comorbid disorders in addition to intraoral pain. These symptoms must be taken into account by clinicians and receive appropriate clinical treatment, as they can significantly affect patients' quality of life.
PB Wiley
SN 1354-523X
YR 2025
FD 2025-11-15
LK https://hdl.handle.net/20.500.14352/129886
UL https://hdl.handle.net/20.500.14352/129886
LA eng
NO de Paiva JPG, Pedroso CM, Muñoz RML, Chmieliauskaite M, Villa A, Jorge J, Santos-Silva AR. Prevalence of Associated Extraoral Symptoms and Comorbidities in Burning Mouth Syndrome Patients: A Systematic Review. Oral Dis. 2025 Nov 15. doi: 10.1111/odi.70144
NO Fundação de Amparo à Pesquisa do Estado de São Paulo and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
DS Docta Complutense
RD 19 mar 2026