RT Journal Article
T1 Characterization of a natural model of adult mice with different rate of aging
A1 Félix Escalera, Judith
A1 Díaz del Cerro, Estefanía
A1 Garrido, Antonio
A1 Fuente Del Rey, María Mónica De La
AB Aging is a heterogeneous process, so individuals of the same age may be aging at a different rate. A natural model of premature aging in mice have been proposed based on the poor response to the T-maze. Those that take longer to cross the intersection are known as Prematurely Aging Mice (PAM), while those that show an exceptional response are known as Exceptional non-PAM (E-NPAM), being the rest non-PAM (NPAM). Although many aspects of PAM and E-NPAM have been described, some aspects of their brain aging have not been studied. Similarly, it is known that PAM, NPAM and E-NPAM show a different rate of aging and longevity, but the differences between these three groups in behavior, immune function and oxidative-inflammatory state are unknown. The present study aims to deepen the study of brain aging in PAM and E-NPAM, and to study the differences in behavior, immunity, and oxidative-inflammatory state of peritoneal leukocytes between PAM, NPAM and E-NPAM. Results show deteriorated brains in PAM. Moreover, NPAM show an oxidative state similar to E-NPAM, an anxiety similar to PAM, and an intermediate immunity and lifespan between PAM and E-NPAM. In conclusion, immune function seems to be more associated with the longevity achieved.
PB Elsevier
SN 0047-6374
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/112162
UL https://hdl.handle.net/20.500.14352/112162
LA eng
NO Félix, J., Díaz-Del Cerro, E., Garrido Tarrío, A., & De La Fuente, M. (2024). Characterization of a natural model of adult mice with different rate of aging. Mechanisms of Ageing and Development, 222. https://doi.org/10.1016/J.MAD.2024.111991
NO This research was funded by the Research Group UCM (910379).
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025