%0 Journal Article
%A Salazar Roa, María
%A Lorente Pérez, María Del Mar
%A García Taboada, Elena
%A Gómez, Eduardo P.
%A Dávila, David
%A Zúñiga García, Patricia
%A Flores Landeira, Juana María
%A Rodríguez, Antonio
%A Hegedus, Zoltan
%A Mosen Ansorena, David
%A Aransay, Ana M.
%A Hernandez Tiedra, Sonia
%A López Valero, Israel
%A Quintanilla, Miguel
%A Sánchez García, María Cristina
%A Iovanna, Juan L
%A Dusetti, Nelson
%A Guzmán Pastor, Manuel
%A Francis, Sheila E.
%A Carracedo, Arkaitz
%A Kiss-Toth, Endre
%A Velasco Díez, Guillermo
%T TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
%D 2015
%U https://hdl.handle.net/20.500.14352/125762
%X In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
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