RT Journal Article
T1 TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
A1 Salazar Roa, María
A1 Lorente Pérez, María Del Mar
A1 García Taboada, Elena
A1 Gómez, Eduardo P.
A1 Dávila, David
A1 Zúñiga García, Patricia
A1 Flores Landeira, Juana María
A1 Rodríguez, Antonio
A1 Hegedus, Zoltan
A1 Mosen Ansorena, David
A1 Aransay, Ana M.
A1 Hernandez Tiedra, Sonia
A1 López Valero, Israel
A1 Quintanilla, Miguel
A1 Sánchez García, María Cristina
A1 Iovanna, Juan L
A1 Dusetti, Nelson
A1 Guzmán Pastor, Manuel
A1 Francis, Sheila E.
A1 Carracedo, Arkaitz
A1 Kiss-Toth, Endre
A1 Velasco Díez, Guillermo
AB In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
PB Taylor and Francis
YR 2015
FD 2015-04
LK https://hdl.handle.net/20.500.14352/125762
UL https://hdl.handle.net/20.500.14352/125762
LA eng
NO Salazar, M., Lorente, M., García-Taboada, E., Gómez, E. P., Dávila, D., Zúñiga-García, P., … Velasco, G. (2015). TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2(3). https://doi.org/10.4161/23723556.2014.980134
DS Docta Complutense
RD 18 mar 2026