RT Journal Article
T1 Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance
A1 García Álvarez, Rafaela
A1 Vallet Regí, María Dulce Nombre
AB Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules present in the media, specially proteins, leading to the formation of the so-called “protein corona”. As a result of these nanomaterial-protein interactions, the bio-identity of the nanomaterial is altered, which is translated into modifications on its behavior, fate and pharmacological profile. For bio- medical applications, it is fundamental to understand the biological behavior of nanomaterials prior to any clinical translation. For these reasons, during the last decade, numerous publications have been focused on the investigation of the protein corona of many different types of nanomaterials. Interestingly, it has been demonstrated that the structure of the protein corona can be divided into hard and soft corona, depending on the affinity of the proteins for the nanoparticle surface. In the present document, we explore the differences between these two protein coronas, review the anal-ysis techniques used for their assessment and reflect on their relevance for medical purposes.
PB MDPI
SN 2079-4991
YR 2021
FD 2021-03-31
LK https://hdl.handle.net/20.500.14352/7962
UL https://hdl.handle.net/20.500.14352/7962
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 12 abr 2025