RT Journal Article
T1 Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics
A1 Ramos Alonso, Eva
A1 Gil Martín, Emilio
A1 Ríos, Cristóbal de los
A1 Egea, Javier
A1 López Muñoz, Francisco
A1 Pita Pita, Rene
A1 Juberías, Antonio
A1 Torrado Durán, Juan José
A1 Serrano López, Dolores Remedios
A1 Reiter, Russel J.
A1 Romero Martínez, Manuel Alejandro
AB Sulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity. Moreover, oxidative/nitrosative stress, inflammatory response induction, metalloproteinases activation, DNA damage or calcium disruption are some of the toxicological mechanisms of sulfur and nitrogen mustard-induced injury that affects the cell integrity and function. In this review, we not only propose melatonin as a therapeutic option in order to counteract and modulate several pathways involved in physiopathological mechanisms activated after exposure to mustards, but also for the first time, we predict whether metabolites of melatonin, cyclic-3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine, and N1-acetyl-5-methoxykynuramine could be capable of exerting a scavenger action and neutralize the toxic damage induced by these blister agents. NLRP3 inflammasome is activated in response to a wide variety of infectious stimuli or cellular stressors, however, although the precise mechanisms leading to activation are not known, mustards are postulated as activators. In this regard, melatonin, through its anti-inflammatory action and NLRP3 inflammasome modulation could exert a protective effect in the pathophysiology and management of sulfur and nitrogen mustard-induced injury. The ability of melatonin to attenuate sulfur and nitrogen mustard-induced toxicity and its high safety profile make melatonin a suitable molecule to be a part of medical countermeasures against blister agents poisoning in the near future.
PB MDPI
SN 2076-3921
YR 2023
FD 2023-02-06
LK https://hdl.handle.net/20.500.14352/105471
UL https://hdl.handle.net/20.500.14352/105471
LA eng
NO Ramos, E.; Gil-Martín, E.; De Los Ríos, C.; Egea, J.; López-Muñoz, F.; Pita, R.; Juberías, A.; Torrado, J.J.; Serrano, D.R.; Reiter, R.J.; et al. Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics. Antioxidants 2023, 12, 397. https://doi.org/10.3390/antiox12020397
DS Docta Complutense
RD 5 abr 2025