RT Journal Article
T1 A unified nomenclature and amino acid numbering for human PTEN.
A1 Pulido, Rafael
A1 Baker, Suzanne J.
A1 Barata, Joao T.
A1 Carracedo, Arkaitz
A1 Cid, Víctor J.
A1 Chin-Sang, Ian D.
A1 Davé, Vrushank
A1 Hertog, Jeroen den
A1 Devreotes, Peter
A1 Eickholt, Britta J.
A1 Eng, Charis
A1 Furnari, Frank B.
A1 Georgescu, María Magdalena
A1 Gericke, Arne
A1 Hopkins, Benjamin
A1 Jiang, Xeujun
A1 Lee, Seung Rock
A1 Lösche, Mathias
A1 Malaney, Prerna
A1 Matias Guiu, Xavier
A1 Molina, María
A1 Pandolfi, Pier Paolo
A1 Parsons, Ramon
A1 Pinton, Paolo
A1 Rivas, Carmen
A1 Rocha, Rafael M.
A1 Rodríguez, Manuel S.
A1 Ross, Alonzo H.
A1 Serrano, Manuel
A1 Stambolic, Vuk
A1 Stiles, Bangyan
A1 Suzuki, Akira
A1 Tan, Seong Seng
A1 Tonks, Nicholas K.
A1 Trotman, Lloyd C.
A1 Wolff, Nicolas
A1 Woscholski, Rudiger
A1 Wu, Hong
A1 Leslie, Nicholas R.
AB The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.
PB American Association for the Advancement of Science
SN 1945-0877
YR 2014
FD 2014-07-01
LK https://hdl.handle.net/20.500.14352/34919
UL https://hdl.handle.net/20.500.14352/34919
LA eng
DS Docta Complutense
RD 8 abr 2025