RT Journal Article
T1 Utility of 1,3 β-d-Glucan Assay for Guidance in Antifungal Stewardship Programs for Oncologic Patients and Solid Organ Transplant Recipients
A1 Machado, Marina
A1 Chamorro De Vega, Esther
A1 Martínez Jiménez, María del Carmen
A1 Rodríguez González, Carmen Guadalupe
A1 Vena, Antonio
A1 Navarro, Raquel
A1 Zamora Cintas, María Isabel
A1 Agnelli, Caroline
A1 Olmedo, María
A1 Galar, Alicia
A1 Guinea, Jesús
A1 Fernández Cruz, Ana
A1 Alonso Fernández, Roberto Alfonso
A1 Bouza, Emilio
A1 Muñoz García, Patricia Carmen
A1 Valerio Minero, Maricela
AB The implementation of 1,3 β-d-glucan (BDG) has been proposed as a diagnostic tool in antifungal stewardship programs (ASPs). We aimed to analyze the influence of serum BDG in an ASP for oncologic patients and solid organ transplant (SOT) recipients. We conducted a pre–post study. In the initial period (PRE), the ASP was based on bedside advice, and this was complemented with BDG in the post-period (POST). Performance parameters of the BDG assay were determined. Antifungal (AF) use adequacy was evaluated using a point score. Clinical outcomes and AF costs were also compared before and after the intervention. Overall, 85 patients were included in the PRE-period and 112 in the POST-period. Probable or proven fungal infections were similar in both groups (54.1% vs. 57.1%; p = 0.67). The determination of BDG contributed to improved management in 75 of 112 patients (66.9%). The AF adequacy score improved in the POST-period (mean 7.75 vs. 9.29; p < 0.001). Median days of empiric AF treatment was reduced in the POST-period (9 vs. 5 days, p = 0.04). All-cause mortality (44.7% vs. 34.8%; p = 0.16) was similar in both periods. The cost of AF treatments was reduced in the POST-period with a difference of 779.6 €/patient. Our data suggest that the use of BDG was a cost-effective strategy that contributed to safely improving the results of an ASP for SOT and oncologic patients.
PB MPDI
SN 2309-608X
YR 2021
FD 2021-01-17
LK https://hdl.handle.net/20.500.14352/7175
UL https://hdl.handle.net/20.500.14352/7175
LA eng
NO Machado, M., Chamorro De Vega, E., Martínez Jimánez, M. C. et al. «Utility of 1,3 β-d-Glucan Assay for Guidance in Antifungal Stewardship Programs for Oncologic Patients and Solid Organ Transplant Recipients». Journal of Fungi, vol. 7, n.o 1, enero de 2021, p. 59. DOI.org (Crossref), https://doi.org/10.3390/jof7010059.
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional
NO Fundación Mutua Madrileña Research
DS Docta Complutense
RD 8 abr 2025