%0 Journal Article
%A Pérez Granda, María Jesús
%A Muñoz García, Patricia Carmen
%A García Martínez, Rita
%A Villalba García, María Victoria
%A Puente Maestu, Luis
%A Bouza Santiago, Emilio
%T Cytomegalovirus reactivation in patients diagnosed with severe COVID-19: A point prevalence study in a general hospital
%D 2023
%@ 0214-3429
%U https://hdl.handle.net/20.500.14352/115708
%X PurposeTo determine the prevalence of CMV reactivation in a population admitted for severe COVID-19 to a general hospital.MethodsPoint prevalence study in all hospitalized patients with severe COVID-19 (admitted either to general wards or ICU). Determination of the presence of CMV DNA in circulating blood. COVID-19 was confirmed in patients with compatible clinical manifestations, usually with pneumonia and a positive nasopharyngeal PCR test.ResultsWe included 140 hospitalized patients with COVID-19 who consented to participate. A total of 16 patients (11.42%), had circulating CMV-DNA in peripheral blood at the time of the study. Patients with positive CMV viral load were mainly ICU patients (11/37 -29,7%) and only 5/103 cases (4,85%) were hospitalized into general wards. The accumulated doses of corticosteroids (prednisone equivalents) in the study day were (median and IQR) 987.50 mg (396.87-2,454.68) and 187.50 mg (75.00-818.12) respectively in CMV positive and negative patients (p < 0.001). A significant proportion of CMV positive patients were discovered because of the study and were clinically unsuspected by their physicians. The coin-fected COVID-CMV positive population had a higher risk of accumulated secondary nosocomially-acquired infections and a worse prognosis.ConclusionCMV reactivation should be systematically searched in patients in COVID-19 cases admitted to the ICU.
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