TY - JOUR AU - Salazar Roa, María AU - Lorente Pérez, María Del Mar AU - Garcia-Taboada, Elena AU - Pérez Gómez, Eduardo AU - Davila, Davila AU - Zuñiga, Patricia AU - Flores Landeira, Juana María AU - Rodriguez, Antonio AU - Hegedus, Zoltán AU - Mosen-Ansorena, David AU - Aransay, Ana María AU - Hernandez-Tiedra, Sonia AU - Lopez-Valero, Israël AU - Quintanilla, Miguel AU - Sánchez García, María Cristina AU - Iovanna, Juan AU - Dusetti, Nelson AU - Guzmán Pastor, Manuel AU - Francis, Sheila AU - Carracedo, Arkaitz AU - Kiss-Toth, Endre AU - Velasco Díez, Guillermo PY - 2014 DO - 10.1038/cdd.2014.133 SN - 1350-9047 UR - https://hdl.handle.net/20.500.14352/96199 T2 - Cell Death and Differentiation AB - Tribbles pseudokinase-3 (TRIB3) has been proposed to act as an inhibitor of AKT although the precise molecular basis of this activity and whether the loss of TRIB3 contributes to cancer initiation and progression remain to be clarified. In this study,... LA - eng M2 - 131 PB - Nature Publishing Group KW - Cancer KW - Tribbles KW - AKT-mTOR axis TI - Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation TY - journal article VL - 22 ER -