RT Journal Article
T1 First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)
A1 Jemni Damer, Nahla
A1 Guedan Duran, Atocha
A1 Cichy, Jasmin
A1 Lozano Picazo, Paloma
A1 Gonzalez Nieto, Daniel
A1 Perez Rigueiro, José
A1 Rojo, Francisco
A1 Guinea, Gustavo V.
A1 Virtuoso, Assunta
A1 Cirillo, GIovanni
A1 Papa, Michele
A1 Armada Maresca, Felix
A1 Largo Aramburu, Carlota
A1 D Aznar Cervantes, Salvador
A1 Cenis, José L.
A1 Panetsos Petrova, Fivos
AB Age-related macular degeneration is an incurable chronic neurodegenerative disease, causing progressive loss of the central vision and even blindness. Up-to-date therapeutic approaches can only slow down he progression of the disease. Objective. Feasibility study for a multilayered, silk fibroin-based, 3D biohybrid retina. Approach. Fabrication of silk fibroin-based biofilms; culture of different types of cells: retinal pigment epithelium, retinal neurons, Müller and mesenchymal stem cells ; creation of a layered structure glued with silk fibroin hydrogel. Main results. In vitro evidence for the feasibility of layered 3D biohybrid retinas; primary culture neurons grow and develop neurites on silk fibroin biofilms, either alone or in presence of other cells cultivated on the same biomaterial; cell organization and cellular phenotypes are maintained in vitro for the seven days of the experiment. Significance. 3D biohybrid retina can be built using silk silkworm fibroin films and hydrogels to be used in cell replacement therapy for AMD and similar retinal neurodegenerative diseases.
PB IOP Science
SN 1741-2552
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/92056
UL https://hdl.handle.net/20.500.14352/92056
LA eng
NO Jemni-Damer, Nahla, et al. «First steps for the development of silk fibroin-based 3D biohybrid retina for age-related macular degeneration (AMD)». Journal of Neural Engineering, vol. 17, n.o 5, octubre de 2020, p. 055003. https://doi.org/10.1088/1741-2552/abb9c0.
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
NO Región de Murcia
DS Docta Complutense
RD 6 abr 2025